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    With enough training, pigeons buying valtrex online safe can distinguish between the works of Picasso and Monet. Ravens can identify themselves in a mirror. And on a university campus in Japan, crows are known to intentionally leave walnuts in a crosswalk and let passing traffic do buying valtrex online safe their nut cracking. Many bird species are incredibly smart. Yet among intelligent animals, the “bird brain” often doesn’t get much respect.

    Two papers published today in Science find birds actually have a brain that is much more similar to our complex primate organ than previously buying valtrex online safe thought. For years it was assumed that the avian brain was limited in function because it lacked a neocortex. In mammals, the neocortex is the hulking, evolutionarily modern outer layer of the brain that allows for complex cognition and creativity and that makes up most of what, in vertebrates as a whole, is called the pallium. The new findings show that birds’ do, in fact, have a brain structure that is comparable to buying valtrex online safe the neocortex despite taking a different shape. It turns out that at a cellular level, the brain region is laid out much like the mammal cortex, explaining why many birds exhibit advanced behaviors and abilities that have long befuddled scientists.

    The new work even suggests that certain buying valtrex online safe birds demonstrate some degree of consciousness. The mammalian cortex is organized into six layers containing vertical columns of neurons that communicate with one another both horizontally and vertically. The avian brain, on the other hand, was thought to be arranged into discrete collections of neurons called nuclei, including a region called the dorsal ventricular ridge, or DVR, and a single nucleus named the wulst. In one of the new papers, senior author Onur Güntürkün, a neuroscientist at Ruhr University Bochum in Germany, and his colleagues analyzed regions of the DVR and buying valtrex online safe wulst involved in sound and vision processing. To do so, they used a technology called three-dimensional polarized light imaging, or 3D-PLI—a light-based microscopy technique that can be employed to visualize nerve fibers in brain samples.

    The researchers found that in both pigeons and barn owls, these brain regions are constructed much like our neocortex, with both layerlike and columnar organization—and with both horizontal and vertical circuitry. They confirmed buying valtrex online safe the 3D-PLI findings using biocytin tracing, a technique for staining nerve cells. [In a Scientific American article, Güntürkün describes how the avian brain demonstrates surprising cognitive abilities.] “We can now claim that this layered, corticallike organization is indeed a feature of the whole sensory forebrain in most, if not all, birds,” says Martin Stacho, co-lead author of the study and Güntürkün’s colleague at Ruhr University Bochum. €œIt’s not that the DVR is the neocortex,” says Vanderbilt University neuroscientist Suzana Herculano-Houzel, who wrote a buying valtrex online safe commentary accompanying the two new papers and was not involved in either of them, “but rather that the whole of the pallium in mammals and in birds has similar developmental origins and connectivity, and therefore [the pallia of both classes] should be considered equivalent structures. Stacho shows that settling for what the naked eye sees can be misleading.” The idea that the DVR was somehow related to the neocortex was proposed in the 1960s by neuroscientist Harvey Karten.

    Yet it didn’t stick. Others subsequently claimed the DVR actually corresponded with other mammalian brain regions, including the amygdala, which, among other tasks, carries out the processing of emotion buying valtrex online safe. €œThe theory about a DVR [correlation] has been possibly one of the biggest disputes in the field of comparative neurobiology,” Stacho says. But his new work lends credibility to Karten’s original hypothesis. Stacho and his colleagues think the findings also represent a glimpse into ancient animal buying valtrex online safe brain evolution.

    The last common ancestor of birds and mammals was a reptile that roamed the earth around 320 million years ago. And its brain, the team believes, was probably a precursor to buying valtrex online safe that of the two lineages that diverged through evolution. €œNobody knows how exactly the brain of the last common ancestor looked like,” Stacho says. €œMost likely, it wasn’t like the neocortex or the DVR. It was probably something in between that, in mammals, developed to a six-layered neocortex and, in birds, to the wulst and DVR.” The other new paper, by a group at the University of Tübingen in Germany, lends still more insight into the avian brain, buying valtrex online safe suggesting that birds have some ability for sensory consciousness—subjective experiences in which they recall sensory experiences.

    Consciousness has long been thought to be localized in the cerebral cortex of smart primates—namely, chimps, bonobos and us humans. Yet crows appear to have at least a rudimentary form of sensory consciousness. In the Tübingen group’s experiment, two carrion crows were trained to recall a previous buying valtrex online safe experience to guide their behavior. When their training was completed, they went through a testing phase in which a gray square might appear followed by either a red or blue square 2.5 seconds later. In this exercise, the crows were trained to move their head if they saw a gray square and then a red one.

    And they learned to buying valtrex online safe keep their head still if they saw a gray square and then a blue one. When the birds saw no stimulus followed by the appearance of a colored square, the sequence was reversed. Blue signaled buying valtrex online safe them to move their head, and red told them not to. So to correctly respond to the colored squares, the crows had to recall whether or not they had seen a gray one first—equating to a past subjective experience. It was crucial to the experiment to present the gray square in six different intensities, including at the threshold of the birds’ perception.

    This way, lead author and neurobiologist Andreas Nieder and his colleagues could confirm that the crows were not simply carrying out conditioned responses to stimuli but instead drawing on a subjective buying valtrex online safe experience. Further, by implanting electrodes in an avian brain region called the nidopallium caudolaterale (NCL), the researchers were able to monitor activity of individual neurons in response to the stimuli. When the crows viewed a dim gray square at their perceptual threshold, NCL neurons became active in the period between that stimulus and the presentation of a colored square—but only if the crows reported seeing the gray one. If they could not detect that square, the neurons remained silent buying valtrex online safe. This result suggests a unique subjective experience was being manifested through neuronal activity.

    Nieder does not claim crows have the self-conscious existence and self-awareness of apes but simply buying valtrex online safe that the birds can partake in a unique, multipart sensory experience in response to a stimulus. €œI am generally not a big fan of ascribing complex humanlike cognitive states to animals and prefer to maintain a conservative attitude,” he says. €œHumans easily start to project their own mental states to other living (or even nonliving) beings. But in terms of sensory consciousness in other species, it is probably fair buying valtrex online safe to assume that advanced vertebrates, such as mammals and birds, possess it.” Nieder’s team’s findings suggest that the neural underpinnings of sensory consciousness either were in place before mammals evolved or developed independently in both lineages—with the avian line showing that being conscious does not necessarily depend on a bulky cerebral cortex. Work by Herculano-Houzel demonstrates that the brains of corvids—members of a family of so-called “smart birds” such as crows, ravens and magpies—are very densely populated with interconnected neurons.

    Her studies jibe with the new Science papers. €œWith Güntürkün’s findings that pallium connectivity is indeed very similar between buying valtrex online safe birds and mammals..., it all comes together very nicely,” she says, pointing out that the corvid pallium holds about as many neurons as you’d find in primates with a much larger brain. This latest research also undercuts primate exceptionalism. €œI hope that more people will be tempted to drop the notion that there is something very unique and exclusive about the human brain,” Herculano-Houzel says..

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    Contact-tracing programs in two areas hit hardest by COVID-19 are working how to get valtrex without a prescription. Catherine Lee, a community health representative, talks with a man at his home on the Navajo Nation. The nation how to get valtrex without a prescription has nearly 200 contact tracers spread across numerous health-care agencies.Jim Thompson/Albuquerque Journal On a mild morning in April at Arizona’s Whiteriver Indian Hospital, Dr. Ryan Close tested nasal swabs from two members of an eight-person household on the Fort Apache Reservation northwest of Phoenix. About half of the family had a runny nose and cough and had lost their sense of taste and smell — all symptoms of COVID-19 — and, by late morning, the two tests had come back positive.

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    An effective how to get valtrex without a prescription contact-tracing and testing plan. Both the White Mountain Apache and nearby Navajo Nation experienced some of the country’s worst infection rates, yet both began to curb their cases in mid-June and mid-July, respectively, due to their existing health department resources and partnerships, stringent public health orders, testing and robust contact tracing. €œWe've seen a significant decline in cases on the reservation at the same time that things were on fire for how to get valtrex without a prescription the rest of the state,” said Close, an epidemiologist and physician at Whiteriver Indian Hospital, an Indian Health Service facility. Tracing disease transmission from COVID-19 is crucial to slowing its spread, but successful contact tracing has proven challenging for communities that lack the funds, community cooperation, personnel or supplies for rapid testing. The White Mountain Apache Tribe of Fort Apache and the Navajo Nation, however, have been growing a contact-tracing army, setting them apart from other tribes during the pandemic.

    As tribal communities brace for multiple waves how to get valtrex without a prescription of COVID-19, public health experts from the two nations have already successfully adapted contact-tracing programs. The White Mountain Apache and the Navajo Nation “were hit hardest early on, and so they have had a little bit more time and opportunity to put these systems into place,” said Laura Hammitt, director of the infectious disease and prevention program at Johns Hopkins Center for American Indian Health, which is working with the Centers for Disease Control to develop a guide for tribal governments to train and grow their own contact-tracing workforces.Across the country, tribes are employing a number of public health measures — closing reservations to nonresidents, setting curfews, providing free testing and aid to families and Indigenous language translations of public health guidelines — but few are actively contact tracing. Contact tracing requires fast how to get valtrex without a prescription and systematic testing and trained personnel. In March, Close trained eight Whiteriver Indian Hospital staffers, but the number has since grown to around 35, serving some 12,000 tribal citizens and residents. The relatively small team takes advantage of the firmly closed reservation boundaries and rapid testing to find and isolate new cases.

    COVID-19 cases were dropping in Fort Apache, which stayed closed, as the state neared its how to get valtrex without a prescription caseload peak in mid-June after the governor lifted stay-at-home orders, becoming one of the country’s worst coronavirus hotspots. Catherine Lee, a community health representative, talks with a man at his home on the Navajo Nation. The nation has nearly 200 contact tracers spread across numerous health-care agencies.Jim Thompson/Albuquerque Journal how to get valtrex without a prescription While most contact-tracing programs rely on phone calls to learn patient history, assess symptoms, encourage isolation and trace other contacts, the Whiteriver team relies on home visits. €œI (can) come to your house to assess you, do a case investigation, or to inform you that you are a contact,” Close said. €œThe benefit of that is that, if you were ill-appearing, they can evaluate you right there.” Tracers can also determine whether other household members are symptomatic, checking temperatures and oxygen saturation, while health-care providers can check breathing with a stethoscope.

    The Whiteriver Hospital can turn around a COVID-19 test in a single day, a process that takes days or weeks at other how to get valtrex without a prescription public health institutions.“We’re not just trying to flatten the curve. We’re trying to actually completely contain this virus.”The Navajo Nation has succeeded in slowing the spread of the new coronavirus, even though the reservation spans three states — New Mexico, Arizona and Utah — so teams must coordinate across several jurisdictions. The nation has nearly how to get valtrex without a prescription 200 contact tracers spread across numerous health-care agencies. With scores of Indigenous communities to monitor over a huge geographic area, phone calls are its primary investigative tool. The Navajo Nation is setting its sights high.

    €œWe’re not just trying to flatten the curve,” said Sonya Shin, who leads tracing investigations for the Nation, “We’re trying to actually completely how to get valtrex without a prescription contain this virus.”Still, critics say it is not enough. The most effective tracing relies on mass testing to catch asymptomatic people as well as those with symptoms. Due to a limited supply of tests, most tribes, like most states, can only test symptomatic people, how to get valtrex without a prescription so the number of cases is inevitably undercounted. €œContact tracing does not mean a damn thing unless you have really good tests, and you’re testing everybody,” said Rudolf Rÿser (Cree/Oneida), executive director of the Center for World Indigenous Studies. €œNot just the people showing the symptoms, but everybody, whether they are Indian or non-Indian, in your area — you have to catch them all.”Kalen Goodluck is a contributing editor at High Country News.

    Email him at [email protected] or submit how to get valtrex without a prescription a letter to the editor.Follow @kalengoodluck Get our Indigenous Affairs newsletter ↓ Thank you for signing up for Indian Country News, an HCN newsletter service. Look for it in your email each month. Read more More from COVID19.

    Contact-tracing programs in buying valtrex online safe two areas hit hardest by COVID-19 are working. Catherine Lee, a community health representative, talks with a man at his home on the Navajo Nation. The nation has nearly 200 contact tracers spread buying valtrex online safe across numerous health-care agencies.Jim Thompson/Albuquerque Journal On a mild morning in April at Arizona’s Whiteriver Indian Hospital, Dr. Ryan Close tested nasal swabs from two members of an eight-person household on the Fort Apache Reservation northwest of Phoenix.

    About half of the family had a runny nose and cough and had lost their sense of taste and smell — all symptoms of COVID-19 — and, by late morning, the two tests had come back positive. Close’s contact-tracing work began.For Close and his team, buying valtrex online safe each day begins like this. With a list of new COVID-19 cases — new sources that may have spread the virus. The 35 or so buying valtrex online safe people on the team must rapidly test people, isolate the infected and visit the homes of any who may have been exposed.

    Again, and again. Recently, though, their cases have declined, due in part to something rare, at least in the United States. An effective contact-tracing and testing buying valtrex online safe plan. Both the White Mountain Apache and nearby Navajo Nation experienced some of the country’s worst infection rates, yet both began to curb their cases in mid-June and mid-July, respectively, due to their existing health department resources and partnerships, stringent public health orders, testing and robust contact tracing.

    €œWe've seen a significant decline in cases on the reservation at the same time that things were on fire for the rest of the state,” said Close, an epidemiologist and physician at Whiteriver Indian Hospital, an Indian buying valtrex online safe Health Service facility. Tracing disease transmission from COVID-19 is crucial to slowing its spread, but successful contact tracing has proven challenging for communities that lack the funds, community cooperation, personnel or supplies for rapid testing. The White Mountain Apache Tribe of Fort Apache and the Navajo Nation, however, have been growing a contact-tracing army, setting them apart from other tribes during the pandemic. As tribal communities brace for multiple waves of COVID-19, public health experts from buying valtrex online safe the two nations have already successfully adapted contact-tracing programs.

    The White Mountain Apache and the Navajo Nation “were hit hardest early on, and so they have had a little bit more time and opportunity to put these systems into place,” said Laura Hammitt, director of the infectious disease and prevention program at Johns Hopkins Center for American Indian Health, which is working with the Centers for Disease Control to develop a guide for tribal governments to train and grow their own contact-tracing workforces.Across the country, tribes are employing a number of public health measures — closing reservations to nonresidents, setting curfews, providing free testing and aid to families and Indigenous language translations of public health guidelines — but few are actively contact tracing. Contact tracing buying valtrex online safe requires fast and systematic testing and trained personnel. In March, Close trained eight Whiteriver Indian Hospital staffers, but the number has since grown to around 35, serving some 12,000 tribal citizens and residents. The relatively small team takes advantage of the firmly closed reservation boundaries and rapid testing to find and isolate new cases.

    COVID-19 cases were dropping in Fort Apache, which stayed closed, as the state neared its caseload peak in mid-June after buying valtrex online safe the governor lifted stay-at-home orders, becoming one of the country’s worst coronavirus hotspots. Catherine Lee, a community health representative, talks with a man at his home on the Navajo Nation. The nation has nearly 200 contact tracers spread across numerous health-care agencies.Jim Thompson/Albuquerque Journal While most contact-tracing programs rely on phone calls to learn patient history, assess symptoms, encourage isolation and trace other contacts, the Whiteriver team buying valtrex online safe relies on home visits. €œI (can) come to your house to assess you, do a case investigation, or to inform you that you are a contact,” Close said.

    €œThe benefit of that is that, if you were ill-appearing, they can evaluate you right there.” Tracers can also determine whether other household members are symptomatic, checking temperatures and oxygen saturation, while health-care providers can check breathing with a stethoscope. The Whiteriver Hospital can turn around a COVID-19 test in a single day, a process that takes days or weeks at other public health buying valtrex online safe institutions.“We’re not just trying to flatten the curve. We’re trying to actually completely contain this virus.”The Navajo Nation has succeeded in slowing the spread of the new coronavirus, even though the reservation spans three states — New Mexico, Arizona and Utah — so teams must coordinate across several jurisdictions. The nation has buying valtrex online safe nearly 200 contact tracers spread across numerous health-care agencies.

    With scores of Indigenous communities to monitor over a huge geographic area, phone calls are its primary investigative tool. The Navajo Nation is setting its sights high. €œWe’re not just buying valtrex online safe trying to flatten the curve,” said Sonya Shin, who leads tracing investigations for the Nation, “We’re trying to actually completely contain this virus.”Still, critics say it is not enough. The most effective tracing relies on mass testing to catch asymptomatic people as well as those with symptoms.

    Due to a limited supply of buying valtrex online safe tests, most tribes, like most states, can only test symptomatic people, so the number of cases is inevitably undercounted. €œContact tracing does not mean a damn thing unless you have really good tests, and you’re testing everybody,” said Rudolf Rÿser (Cree/Oneida), executive director of the Center for World Indigenous Studies. €œNot just the people showing the symptoms, but everybody, whether they are Indian or non-Indian, in your area — you have to catch them all.”Kalen Goodluck is a contributing editor at High Country News. Email him at [email protected] or submit a letter to the editor.Follow @kalengoodluck Get our Indigenous Affairs newsletter ↓ Thank you buying valtrex online safe for signing up for Indian Country News, an HCN newsletter service.

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